Panels, Double, and Triple Stains
PANELS
Lung Panel (P40, TTF1 – Napsin A): Used to differentiate between lung adenocarcinoma and squamous cell carcinoma of the lung.
DOUBLE STAINS
Pan Keratin – p63: For evaluation of microinvasion in small breast biopsies
Cytokeratin 34β12 (K903) – Racemase (p504s): For evaluation of small foci of invasive prostate carcinoma
P40 – Cytokeratin 5/6: For evaluation of lung SCC
TTF1 Brown – Napsin A: For confirmation of glandular differentiation in small lung biopsies
TRIPLE STAINS
Racemase – p63 – Cytokeratin 34βE12 (K903) (Prostate): For evaluation of small foci of invasive prostate carcinoma
p63 – Cytokeratin 5 – Cytokeratin 8/18 (Breast): P63 labels the nuclei of myoepithelial cells. Cytokeratin 5 is a high molecular weight cytokeratin which labels the cytoplasm of myoepithelial cells. Cytokeratin 8/18 is a low molecular weight cytokeratin which stains the cytoplasm of all ductal or lobular epithelium. Used together as a triple stain, they can differentiate between usual ductal hyperplasia and atypical ductal hyperplasia, can distinguish ductal carcinoma in situ from microinvasive breast carcinoma, and can identify basal phenotypes